Therapeutic drug monitoring for mycophenolic acid in patients with autoimmune diseases
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چکیده
منابع مشابه
Therapeutic drug monitoring for mycophenolic acid in patients with autoimmune diseases.
Mycophenolate mofetil (MMF, CellCept R © ) has become the most frequently used immunosuppressive drug in kidney transplant recipients [1]. Since its approval for the prevention of acute rejection after kidney transplantation in 1995 in the USA and in 1996 in Europe, the use of azathioprine has been rapidly diminishing, giving way to the use of MMF. A second formulation of mycophenolic acid (MPA...
متن کاملDiagnostic and Therapeutic Corner Therapeutic Drug Monitoring of Mycophenolic Acid
M ycophenolic acid (MPA)-based therapies are widely used in combination with calcineurin inhibitors as maintenance immunosuppression for kidney transplant recipients (1). The two MPA therapies used in clinical transplantation are mycophenolate mofetil (MMF [brand name CellCept, Roche Pharmaceuticals, Nutley, NJ]) and mycophenolate sodium (MPS [brand name Myfortic, Norvartis Pharmaceuticals, Nut...
متن کاملTherapeutic Drug Monitoring of Valproic Acid in Patients with Monotherapy at Steady State
Objective(s) The role of therapeutic drug monitoring (TDM) in patient care has grown rapidly since its introduction three decades ago. The aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (VPA). Materials and Methods In the present study we evaluated a homogeneous group of adult patients receiving VPA monotherapy. ...
متن کاملNonlinear relationship between mycophenolate mofetil dose and mycophenolic acid exposure: implications for therapeutic drug monitoring.
BACKGROUND AND OBJECTIVES Mycophenolate mofetil (MMF) is an immunosuppressive drug used in renal transplant patients. Upon oral administration it is hydrolyzed to the active agent mycophenolic acid (MPA). In renal transplant recipients, MMF therapy is optimal when the area under the curve of MPA is 30 to 60 mg·h/L. When MMF doses are adjusted, a linear relationship between dose and MPA exposure...
متن کاملConsensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation.
With the increasing use of mycophenolic acid (MPA) in solid organ transplantation, the need for more accurate drug dosing has become evident. Personalized immunosuppressive therapy requires better strategies for avoidance of drug-related toxicity while maintaining efficacy. Few studies have assessed the clinical usefulness of therapeutic drug monitoring (TDM) of MPA in solid organ transplantati...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2008
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfn497